5ywy: Difference between revisions
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The | ==Crystal structure of the clinically important GPCR in complex with functional antibody.== | ||
<StructureSection load='5ywy' size='340' side='right' caption='[[5ywy]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ywy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YWY FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7UR:4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic+acid'>7UR</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ywy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywy OCA], [http://pdbe.org/5ywy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ywy RCSB], [http://www.ebi.ac.uk/pdbsum/5ywy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywy ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PE2R4_HUMAN PE2R4_HUMAN]] Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Horita, S]] | |||
[[Category: Iwata, S]] | |||
[[Category: Kobayashi, T]] | |||
[[Category: Morimoto, K]] | |||
[[Category: Suno, R]] | |||
[[Category: Toyoda, Y]] | |||
[[Category: Functional antibody]] | |||
[[Category: G-protein coupled receptor]] | |||
[[Category: Lipid mediator]] | |||
[[Category: Membrane protein]] | |||
[[Category: Signaling protein-immune system]] | |||
[[Category: Signaling protein-immune system complex]] | |||
Revision as of 06:29, 5 December 2018
Crystal structure of the clinically important GPCR in complex with functional antibody.
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