2cn5: Difference between revisions

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[[Image:2cn5.gif|left|200px]]
[[Image:2cn5.gif|left|200px]]


{{Structure
<!--
|PDB= 2cn5 |SIZE=350|CAPTION= <scene name='initialview01'>2cn5</scene>, resolution 2.25&Aring;
The line below this paragraph, containing "STRUCTURE_2cn5", creates the "Structure Box" on the page.
|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_2cn5| PDB=2cn5  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cn5 OCA], [http://www.ebi.ac.uk/pdbsum/2cn5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cn5 RCSB]</span>
}}


'''CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH ADP'''
'''CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH ADP'''
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[[Category: Oliver, A W.]]
[[Category: Oliver, A W.]]
[[Category: Pearl, L H.]]
[[Category: Pearl, L H.]]
[[Category: activation segment]]
[[Category: Activation segment]]
[[Category: alternative splicing]]
[[Category: Alternative splicing]]
[[Category: atp-binding]]
[[Category: Atp-binding]]
[[Category: cancer]]
[[Category: Cancer]]
[[Category: cds1]]
[[Category: Cds1]]
[[Category: cell cycle]]
[[Category: Cell cycle]]
[[Category: checkpoint]]
[[Category: Checkpoint]]
[[Category: chek2]]
[[Category: Chek2]]
[[Category: chk2]]
[[Category: Chk2]]
[[Category: disease mutation]]
[[Category: Disease mutation]]
[[Category: kinase]]
[[Category: Kinase]]
[[Category: kinase domain]]
[[Category: Kinase domain]]
[[Category: li-fraumeni syndrome]]
[[Category: Li-fraumeni syndrome]]
[[Category: magnesium]]
[[Category: Magnesium]]
[[Category: metal-binding]]
[[Category: Metal-binding]]
[[Category: nuclear protein]]
[[Category: Nuclear protein]]
[[Category: nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: phosphorylation]]
[[Category: Phosphorylation]]
[[Category: proto-oncogene]]
[[Category: Proto-oncogene]]
[[Category: rad53]]
[[Category: Rad53]]
[[Category: serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: transferase]]
[[Category: Transferase]]
[[Category: tumour suppressor]]
[[Category: Tumour suppressor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 22:33:53 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:23:52 2008''

Revision as of 19:33, 3 May 2008

File:2cn5.gif

Template:STRUCTURE 2cn5

CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH ADP


Overview

The protein kinase Chk2 (checkpoint kinase 2) is a major effector of the replication checkpoint. Chk2 activation is initiated by phosphorylation of Thr68, in the serine-glutamine/threonine-glutamine cluster domain (SCD), by ATM. The phosphorylated SCD-segment binds to the FHA domain of a second Chk2 molecule, promoting dimerisation of the protein and triggering phosphorylation of the activation segment/T-loop in the kinase domain. We have now determined the structure of the kinase domain of human Chk2 in complexes with ADP and a small-molecule inhibitor debromohymenialdisine. The structure reveals a remarkable dimeric arrangement in which T-loops are exchanged between protomers, to form an active kinase conformation in trans. Biochemical data suggest that this dimer is the biologically active state promoted by ATM-phosphorylation, and also suggests a mechanism for dimerisation-driven activation of Chk2 by trans-phosphorylation.

About this Structure

2CN5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange., Oliver AW, Paul A, Boxall KJ, Barrie SE, Aherne GW, Garrett MD, Mittnacht S, Pearl LH, EMBO J. 2006 Jul 12;25(13):3179-90. Epub 2006 Jun 22. PMID:16794575 Page seeded by OCA on Sat May 3 22:33:53 2008

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