6bwr: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6bwr is ~~ON HOLD~~ ~~until Paper Publication~~

==LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with nickel==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6bwr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BWR FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwr OCA], [http://pdbe.org/6bwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bwr RCSB], [http://www.ebi.ac.uk/pdbsum/6bwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwr ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/LARC_LACPL LARC_LACPL]] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is required for the activation of the lactate racemase LarA. May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes.<ref>PMID:24710389</ref> <ref>PMID:27114550</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Fellner, M]]

[[Category: Hausinger, R P]]

[[Category: Hu, J]]

[[Category: Ctp]]

[[Category: Hexamer]]

[[Category: Lactate]]

[[Category: Lactate racemase]]

[[Category: Lactate racemization]]

[[Category: Lar]]

[[Category: Larc]]

[[Category: Metal binding protein]]

[[Category: Nickel]]

[[Category: Nickel transferase]]

[[Category: Trimer]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6bwr is ON HOLD  until Paper Publication
+==LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with nickel==
+<StructureSection load='6bwr' size='340' side='right' caption='[[6bwr]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6bwr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BWR FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwr OCA], [http://pdbe.org/6bwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bwr RCSB], [http://www.ebi.ac.uk/pdbsum/6bwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwr ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/LARC_LACPL LARC_LACPL]] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is required for the activation of the lactate racemase LarA. May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes.<ref>PMID:24710389</ref> <ref>PMID:27114550</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Fellner, M]]
+[[Category: Hausinger, R P]]
+[[Category: Hu, J]]
+[[Category: Ctp]]
+[[Category: Hexamer]]
+[[Category: Lactate]]
+[[Category: Lactate racemase]]
+[[Category: Lactate racemization]]
+[[Category: Lar]]
+[[Category: Larc]]
+[[Category: Metal binding protein]]
+[[Category: Nickel]]
+[[Category: Nickel transferase]]
+[[Category: Trimer]]