6fae: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "6fae" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
The | ==The Sec7 domain of IQSEC2 (Brag1) in complex with the small GTPase Arf1== | ||
<StructureSection load='6fae' size='340' side='right' caption='[[6fae]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6fae]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FAE FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fae OCA], [http://pdbe.org/6fae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fae RCSB], [http://www.ebi.ac.uk/pdbsum/6fae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fae ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/IQEC2_HUMAN IQEC2_HUMAN]] Severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome;X-linked non-syndromic intellectual disability. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/IQEC2_HUMAN IQEC2_HUMAN]] Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins.<ref>PMID:26793055</ref> [[http://www.uniprot.org/uniprot/ARF1_HUMAN ARF1_HUMAN]] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Brennan, P]] | |||
[[Category: Delft, F von]] | |||
[[Category: Edwards, A]] | |||
[[Category: Fairhead, M]] | |||
[[Category: Gray, J]] | [[Category: Gray, J]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
[[Category: | [[Category: Gtpase gef]] | ||
[[Category: | [[Category: Hydrolase]] | ||
Revision as of 07:11, 17 January 2018
The Sec7 domain of IQSEC2 (Brag1) in complex with the small GTPase Arf1
| ||||||||||||
