1fi2

CRYSTAL STRUCTURE OF GERMIN (OXALATE OXIDASE)

spinqualitylabelsall models 1fi2, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1fi2 is a 1 chain structure with sequence from Hordeum vulgare. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MN Related: 2phl Activity: Oxalate oxidase, with EC number 1.2.3.4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [OXO1_HORVU] Releases hydrogen peroxide in the apoplast which may be important for cross-linking reactions in the cell wall biochemistry. May play an important role in several aspects of plant growth and defense mechanisms. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Germin is a hydrogen peroxide generating oxalate oxidase with extreme thermal stability; it is involved in the defense against biotic and abiotic stress in plants. The structure, determined at 1.6 A resolution, comprises beta-jellyroll monomers locked into a homohexamer (a trimer of dimers), with extensive surface burial accounting for its remarkable stability. The germin dimer is structurally equivalent to the monomer of the 7S seed storage proteins (vicilins), indicating evolution from a common ancestral protein. A single manganese ion is bound per germin monomer by ligands similar to those of manganese superoxide dismutase (MnSOD). Germin is also shown to have SOD activity and we propose that the defense against extracellular superoxide radicals is an important additional role for germin and related proteins. Germin is a manganese containing homohexamer with oxalate oxidase and superoxide dismutase activities.,Woo EJ, Dunwell JM, Goodenough PW, Marvier AC, Pickersgill RW Nat Struct Biol. 2000 Nov;7(11):1036-40. PMID:11062559 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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