Aconitase: Difference between revisions
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== Cytosolic aconitase and its other function == | == Cytosolic aconitase and its other function == | ||
A specialty of cAc is that in mammals it has developed a <scene name=' | A specialty of cAc is that in mammals it has developed a <scene name='33/338089/Cv/2'>second function</scene> as inhibitor of <scene name='33/338089/Cv/3'>those mRNA</scene> that carry an <scene name='33/338089/Cv/4'>iron-responsive element (IRE)</scene>. Therefore, the cytosolic cAc is named IREBP for IRE-binding protein when this function is talked about. Only one of the two functions is active, depending on whether <scene name='Aconitase/2b3x-cluster/1'>the (4Fe-4S) cofactor</scene> is present in the molecule: it's essential for <scene name='Aconitase/2b3x-total/1'>the ACO function</scene>. You can see, by <scene name='Aconitase/Morph/2'>looking at the morph</scene>, how much the enzyme structure differs between those two functions. | ||
Along with serving as a catalyst, aconitase is a member of the iron regulatory protien-1 (IRP-1) family. These enzymes have been found to play a role in regulatory RNA-binding proteins. This suggests a novel role for Fe-S clusters as post-translational regulatory switches.<ref name="Frishman" /> | Along with serving as a catalyst, aconitase is a member of the iron regulatory protien-1 (IRP-1) family. These enzymes have been found to play a role in regulatory RNA-binding proteins. This suggests a novel role for Fe-S clusters as post-translational regulatory switches.<ref name="Frishman" /> | ||
