5z1w: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5z1w is ~~ON HOLD~~

==Cryo-EM structure of polycystic kidney disease-like channel PKD2L1==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5z1w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z1W FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z1w OCA], [http://pdbe.org/5z1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z1w RCSB], [http://www.ebi.ac.uk/pdbsum/5z1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z1w ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PK2L1_MOUSE PK2L1_MOUSE]] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. May play a role in the perception of carbonation taste.<ref>PMID:15548533</ref> <ref>PMID:16891422</ref> <ref>PMID:16929298</ref> <ref>PMID:19833970</ref> <ref>PMID:21098668</ref> <ref>PMID:21625513</ref> <ref>PMID:24336288</ref> <ref>PMID:24336289</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Zhang, Y Q]]

[[Category: Channel]]

[[Category: Cryo-em]]

[[Category: Membrane protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5z1w is ON HOLD
+==Cryo-EM structure of polycystic kidney disease-like channel PKD2L1==
+<StructureSection load='5z1w' size='340' side='right' caption='[[5z1w]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5z1w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z1W FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z1w OCA], [http://pdbe.org/5z1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z1w RCSB], [http://www.ebi.ac.uk/pdbsum/5z1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z1w ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PK2L1_MOUSE PK2L1_MOUSE]] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. May play a role in the perception of carbonation taste.<ref>PMID:15548533</ref> <ref>PMID:16891422</ref> <ref>PMID:16929298</ref> <ref>PMID:19833970</ref> <ref>PMID:21098668</ref> <ref>PMID:21625513</ref> <ref>PMID:24336288</ref> <ref>PMID:24336289</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Zhang, Y Q]]
+[[Category: Channel]]
+[[Category: Cryo-em]]
+[[Category: Membrane protein]]