GTP-binding protein: Difference between revisions
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== Function == | == Function == | ||
'''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: '''heterotrimeric G proteins'''<ref>PMID:14762218</ref> see [[Transducin]] and '''small GTPases'''<ref>PMID:11152757</ref>. The structure of small GTPase is homologous to that of the α subunit of heterotrimeric G protein. See details on small GTP-binding protein LepA in [[LepA]]. | '''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: '''heterotrimeric G proteins'''<ref>PMID:14762218</ref> see [[Transducin]] and '''small GTPases'''<ref>PMID:11152757</ref>. The structure of small GTPase is homologous to that of the α subunit of heterotrimeric G protein. See details on '''small GTP-binding protein LepA''' in [[LepA]]. | ||
'''Heterotrimeric G protein or guanine nucleotide-binding protein or G protein''' (GNBP) are heterodimeric membrane proteins composed of α, β and γ subunits. GNBP is involved in mammalian cellular signaling pathways. GNBP α subunit binds GDP or GTP. When bound to GTP it dissociates from the β and γ subunits, binds to adenylate cyclase which converts ATP to cAMP. | '''Heterotrimeric G protein or guanine nucleotide-binding protein or G protein''' (GNBP) are heterodimeric membrane proteins composed of α, β and γ subunits. GNBP is involved in mammalian cellular signaling pathways. GNBP α subunit binds GDP or GTP. When bound to GTP it dissociates from the β and γ subunits, binds to adenylate cyclase which converts ATP to cAMP. See also<br /> | ||
[[G protein-coupled receptor]]<br /> | [[G protein-coupled receptor]]<br /> | ||
[[Beta2 adrenergic receptor-Gs protein complex]]. | [[Beta2 adrenergic receptor-Gs protein complex]]. | ||
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**[[2qtf]] – SsHflx<br /> | **[[2qtf]] – SsHflx<br /> | ||
**[[2dyk]] – TtEngA N terminal – ''Thermus thermophilus'' - Cryo EM<br /> | **[[2dyk]] – TtEngA N terminal – ''Thermus thermophilus'' - Cryo EM<br /> | ||
**[[5a9v]], [[4zci]] – EcBipA – ''Escherichia coli'' <br /> | |||
**[[5a9v]], [[4zci]] – EcBipA | |||
**[[4zck]] – EcBipA C-terminal<br /> | **[[4zck]] – EcBipA C-terminal<br /> | ||
**[[1sul]] – BsYsxC - ''Bacillus subtilis''<br /> | **[[1sul]] – BsYsxC - ''Bacillus subtilis''<br /> | ||
**[[2dwq]] – TtYchF<br /> | **[[2dwq]] – TtYchF<br /> | ||
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**[[1yr9]], [[1yra]], [[1yrb]], [[2oxr]] – PaGBP + GDP<br /> | **[[1yr9]], [[1yra]], [[1yrb]], [[2oxr]] – PaGBP + GDP<br /> | ||
**[[3kxi]], [[2qth]] – SsHflx + GDP<br /> | **[[3kxi]], [[2qth]] – SsHflx + GDP<br /> | ||
**[[1yzn]] – yPt1 + GPPNHP<br /> | **[[1yzn]] – yPt1 + GPPNHP<br /> | ||
**[[1ky2]] – yPt7 + GPPNHP<br /> | **[[1ky2]] – yPt7 + GPPNHP<br /> | ||
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*GTP-binding protein complex with protein | *GTP-binding protein complex with protein | ||
**[[3cue]] – yPt1 + transport protein subunits<br /> | **[[3cue]] – yPt1 + transport protein subunits<br /> | ||
**[[2bcg]], [[1ukv]] - yPt1 + secretory pathway GDP-dissociation inhibitor<br /> | **[[2bcg]], [[1ukv]] - yPt1 + secretory pathway GDP-dissociation inhibitor<br /> | ||
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**[[4idn]] – hGDP3 cytoplasmic domain + GNP<br /> | **[[4idn]] – hGDP3 cytoplasmic domain + GNP<br /> | ||
**[[4ido]], [[4idq]], [[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hGDP3 cytoplasmic domain + GDP<br /> | **[[4ido]], [[4idq]], [[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hGDP3 cytoplasmic domain + GDP<br /> | ||
* GTP-binding protein LepA | |||
**[[3cb4]] – EcLepA <br /> | |||
**[[2ywe]] – AaLepA – ''Aquifex aeolicus''<br /> | |||
**[[4k8w]] – LepA – ''Streptococcus pyogenes''<br /> | |||
**[[2ywf]] – AaLepA + GMP-PNP<br /> | |||
**[[2ywg]] - AaLepA + GTP<br /> | |||
**[[2ywh]] - AaLepA + GDP<br /> | |||
**[[3deg]] – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM<br /> | |||
*G protein bound to a G protein-coupled receptor | *G protein bound to a G protein-coupled receptor | ||
