5wnb: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5wnb is ~~ON HOLD~~ ~~until Paper Publication~~

==Structure of antibody 3D3 bound to the linear epitope of RSV G==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5wnb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNB FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnb OCA], [http://pdbe.org/5wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wnb RCSB], [http://www.ebi.ac.uk/pdbsum/5wnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnb ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.

__TOC__

</StructureSection>

[[Category: DuBois, R M]]

[[Category: Fedechkin, S O]]

[[Category: George, N L]]

[[Category: Kauvar, L M]]

[[Category: Wolff, J T]]

[[Category: Antibody]]

[[Category: G glycoprotein]]

[[Category: Glycoprotein]]

[[Category: Rsv]]

[[Category: Viral attachment protein]]

[[Category: Viral protein]]

[[Category: Viral protein-immune system complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5wnb is ON HOLD  until Paper Publication
+==Structure of antibody 3D3 bound to the linear epitope of RSV G==
+<StructureSection load='5wnb' size='340' side='right' caption='[[5wnb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5wnb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNB FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnb OCA], [http://pdbe.org/5wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wnb RCSB], [http://www.ebi.ac.uk/pdbsum/5wnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities.  Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.
+__TOC__
+</StructureSection>
+[[Category: DuBois, R M]]
+[[Category: Fedechkin, S O]]
+[[Category: George, N L]]
+[[Category: Kauvar, L M]]
+[[Category: Wolff, J T]]
+[[Category: Antibody]]
+[[Category: G glycoprotein]]
+[[Category: Glycoprotein]]
+[[Category: Rsv]]
+[[Category: Viral attachment protein]]
+[[Category: Viral protein]]
+[[Category: Viral protein-immune system complex]]