6btv: Difference between revisions
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==Solution NMR structures for CcoTx-II== | |||
<StructureSection load='6btv' size='340' side='right' caption='[[6btv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6btv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BTV FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6br0|6br0]]</td></tr> | ||
[[Category: Agwa, A | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6btv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6btv OCA], [http://pdbe.org/6btv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6btv RCSB], [http://www.ebi.ac.uk/pdbsum/6btv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6btv ProSAT]</span></td></tr> | ||
[[Category: Schroeder, C | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TX2_CERMR TX2_CERMR]] Inhibits several voltage-gated sodium channels and only one voltage-gated calcium channel (Cav2.2/CACNA1B (IC(50)=1100 nM) and Nav1.2/SCN2A (IC(50)=8-80 nM), Nav1.3/SCN3A (88-5570 nM), Nav1.1/SCN1A (170-407 nM), Nav1.7/SCN9A (230 nM), Nav1.6/SCN6A (3990 nM), Nav1.4/SCN4A (400 nM or >10 uM), Nav1.5/SCN5A (1634 nM or >10 uM)) (PubMed:16267209, PubMed:28880874). The toxin acts by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the sodium current (PubMed:16267209). In vivo, this toxin causes general ataxia, lack of response to stimuli, and semiparalysis (PubMed:16267209). After a few minutes, the mice are unable to stand, and breathing is reduced in rhythm and intensity (PubMed:16267209). Symptoms gradually increase with progressive slowing of breathing and flaccid paralysis; death occurred within 10 to 20 minutes post injection (PubMed:16267209). Animals remain totally flaccid, and no symptoms of excitatory neurotoxicity are observed (PubMed:16267209).<ref>PMID:16267209</ref> <ref>PMID:28880874</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Agwa, A J]] | |||
[[Category: Schroeder, C I]] | |||
[[Category: Disulfide]] | |||
[[Category: Ick]] | |||
[[Category: Nav1 7]] | |||
[[Category: Pain]] | |||
[[Category: Spider]] | |||
[[Category: Toxin]] | |||
[[Category: Voltage gated ion channel]] | |||
Revision as of 06:15, 9 May 2018
Solution NMR structures for CcoTx-II
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