6bwn: Difference between revisions
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==Crystal Structure of Mouse Protocadherin-15 EC6-7== | |||
<StructureSection load='6bwn' size='340' side='right' caption='[[6bwn]], [[Resolution|resolution]] 2.94Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bwn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BWN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwn OCA], [http://pdbe.org/6bwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bwn RCSB], [http://www.ebi.ac.uk/pdbsum/6bwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwn ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Klanseck, C F]] | |||
[[Category: Neel, B L]] | |||
[[Category: Sotomayor, M]] | |||
[[Category: Adhesion]] | |||
[[Category: Calcium-binding protein]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Hearing]] | |||
[[Category: Mechanotransduction]] | |||