6fgk: Difference between revisions
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==Crystal structure of the small alarmone synthethase 2 from Bacillus subtilis== | |||
<StructureSection load='6fgk' size='340' side='right' caption='[[6fgk]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6fgk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FGK FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fhj|6fhj]]</td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/GTP_diphosphokinase GTP diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.5 2.7.6.5] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fgk OCA], [http://pdbe.org/6fgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fgk RCSB], [http://www.ebi.ac.uk/pdbsum/6fgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fgk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/YWAC_BACSU YWAC_BACSU]] Functions as a (p)ppGpp synthase; GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis (PubMed:18067544). Overexpression in relA mutants (triple relA-yjbM-ywaC deletions and single relA deletions) leads to growth arrest; GTP levels fall drastically, various guanine-related nucleotides are synthesized (ppGp or pGpp), the cellular transcriptional profile changes dramatically and 70S ribosome dimerization occurs (PubMed:22950019). Overexpression in the presence of a wild-type relA gene does not have these effects (PubMed:22950019). In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. activities in response to changes in nutritional abundance. YwaC has probably a minor role in stringent response (PubMed:18067544).<ref>PMID:18067544</ref> <ref>PMID:22950019</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: GTP diphosphokinase]] | |||
[[Category: Altegoer, F]] | |||
[[Category: Bange, G]] | [[Category: Bange, G]] | ||
[[Category: Steinchen, W]] | [[Category: Steinchen, W]] | ||
[[Category: Vogt, M]] | [[Category: Vogt, M]] | ||
[[Category: Alarmone]] | |||
[[Category: Relp]] | |||
[[Category: Sas2]] | |||
[[Category: Stringent response]] | |||
[[Category: Transferase]] | |||
Revision as of 06:24, 7 February 2018
Crystal structure of the small alarmone synthethase 2 from Bacillus subtilis
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