Sandbox Reserved 1063: Difference between revisions
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Adhesin Competence Regulator (<scene name='69/694230/Adcr_space_fill/1'>AdcR</scene>) is a transcriptional regulator that controls the activation of over seventy genes within the bacterium [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae''Streptococcus pneumoniae''] <ref name="Sanson">DOI:10.1093/nar/gku1304 </ref> and is a member of the multiple antibiotic resistance regulator (MarR) protein family <ref> PMID: 23428319</ref>. Members of the Mar R protein family conserve a number of features including a general triangular shape, a two fold pseudosymmetric homodimer, and a winged helix-turn-helix pattern [https://en.wikipedia.org/wiki/Helix-turn-helix (wHTH)] which can be seen in Figure 1. AdcR exhibits these conserved features as well, while also exhibiting its own distinct features. | Adhesin Competence Regulator (<scene name='69/694230/Adcr_space_fill/1'>AdcR</scene>) is a transcriptional regulator that controls the activation of over seventy genes within the bacterium [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae''Streptococcus pneumoniae''] <ref name="Sanson">DOI:10.1093/nar/gku1304 </ref> and is a member of the multiple antibiotic resistance regulator (MarR) protein family <ref> PMID: 23428319</ref>. Members of the Mar R protein family conserve a number of features including a general triangular shape, a two fold pseudosymmetric homodimer, and a winged helix-turn-helix pattern [https://en.wikipedia.org/wiki/Helix-turn-helix (wHTH)] which can be seen in Figure 1. AdcR exhibits these conserved features as well, while also exhibiting its own distinct features. | ||
[[Image:MarR_protein_family_slide.png|500px|left|thumb|'''Figure 1'''. Proteins MarR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3bpx (3BPX)], HucR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2FBK (2FBK)], TcaR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3KP5 (3KP5)], and OhrR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2pfb (2PFB)] are pictured above with conserved features of the MarR protein family highlighted]] | [[Image:MarR_protein_family_slide.png|500px|left|thumb|'''Figure 1: MarR protein family features'''. Proteins MarR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3bpx (3BPX)], HucR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2FBK (2FBK)], TcaR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3KP5 (3KP5)], and OhrR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2pfb (2PFB)] are pictured above with conserved features of the MarR protein family highlighted]] | ||
In contrast with other members of the MarR family, AdcR is metal dependent. Zinc plays a vital role in organism homeostasis, acting as a [https://en.wikipedia.org/wiki/Cofactor_(biochemistry) co-factor] and a regulator of enzymatic activity. However zinc can lead to cell toxicity and deficiency of other vital metals that are also necessary for protein function <ref> DOI: 10.1021/cr900077w</ref>. Binding of Zinc allows AdcR to bind DNA and activate the transcription of high-affinity Zinc specific uptake transporters. The importance of AdcR in ''Streptococcus pneumoniae'' can be understood provided its ability to regulate zinc transfer proteins within the bacteria. | In contrast with other members of the MarR family, AdcR is metal dependent. Zinc plays a vital role in organism homeostasis, acting as a [https://en.wikipedia.org/wiki/Cofactor_(biochemistry) co-factor] and a regulator of enzymatic activity. However zinc can lead to cell toxicity and deficiency of other vital metals that are also necessary for protein function <ref> DOI: 10.1021/cr900077w</ref>. Binding of Zinc allows AdcR to bind DNA and activate the transcription of high-affinity Zinc specific uptake transporters. The importance of AdcR in ''Streptococcus pneumoniae'' can be understood provided its ability to regulate zinc transfer proteins within the bacteria. | ||
