6bgl: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6bgl is ~~ON HOLD until Paper Publication~~

==Doubly PafE-capped 20S core particle in Mycobacterium tuberculosis==

~~Authors~~: Li, H., Hu, K.

== Structural highlights ==

<table><tr><td colspan='2'>[[6bgl]] is a 42 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BGL OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BGL FirstGlance].

~~Description~~: ~~Doubly PafE~~-~~capped 20S core particle~~ in ~~Mycobacterium tuberculosis~~

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bgl OCA], [http://pdbe.org/6bgl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bgl RCSB], [http://www.ebi.ac.uk/pdbsum/6bgl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bgl ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PSA_MYCTA PSA_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. [[http://www.uniprot.org/uniprot/PSB_MYCTA PSB_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. [[http://www.uniprot.org/uniprot/BPA_MYCTO BPA_MYCTO]] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.[UniProtKB:P9WKX3]

__TOC__

</StructureSection>

[[Category: Proteasome endopeptidase complex]]

[[Category: Hu, K]]

[[Category: Li, H]]

[[Category: ~~Hu, K~~]]

[[Category: Hydrolase]]

[[Category: Protein degradation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6bgl is ON HOLD  until Paper Publication
+==Doubly PafE-capped 20S core particle in Mycobacterium tuberculosis==
+<StructureSection load='6bgl' size='340' side='right' caption='[[6bgl]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-Authors: Li, H., Hu, K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6bgl]] is a 42 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BGL FirstGlance]. <br>
-Description: Doubly PafE-capped 20S core particle in Mycobacterium tuberculosis
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bgl OCA], [http://pdbe.org/6bgl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bgl RCSB], [http://www.ebi.ac.uk/pdbsum/6bgl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bgl ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PSA_MYCTA PSA_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. [[http://www.uniprot.org/uniprot/PSB_MYCTA PSB_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. [[http://www.uniprot.org/uniprot/BPA_MYCTO BPA_MYCTO]] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.[UniProtKB:P9WKX3]
+__TOC__
+</StructureSection>
+[[Category: Proteasome endopeptidase complex]]
+[[Category: Hu, K]]
 [[Category: Li, H]]
-[[Category: Hu, K]]
+[[Category: Hydrolase]]
+[[Category: Protein degradation]]