6c48: Difference between revisions
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==Crystal structure of B-Myb-LIN9-LIN52 complex== | |||
<StructureSection load='6c48' size='340' side='right' caption='[[6c48]], [[Resolution|resolution]] 2.32Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6c48]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C48 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[ | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
[[Category: Guiley, K | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c48 OCA], [http://pdbe.org/6c48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c48 RCSB], [http://www.ebi.ac.uk/pdbsum/6c48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c48 ProSAT]</span></td></tr> | ||
[[Category: Rubin, S | </table> | ||
[[Category: Tripathi, S | == Function == | ||
[[http://www.uniprot.org/uniprot/LIN9_HUMAN LIN9_HUMAN]] Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.<ref>PMID:15538385</ref> <ref>PMID:16730350</ref> [[http://www.uniprot.org/uniprot/MYBB_HUMAN MYBB_HUMAN]] Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.<ref>PMID:10770937</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Guiley, K Z]] | |||
[[Category: Rubin, S M]] | |||
[[Category: Tripathi, S M]] | |||
[[Category: B-myb]] | |||
[[Category: Cell cycle]] | |||
[[Category: Cell cycle-dna binding complex]] | |||
[[Category: Lin52]] | |||
[[Category: Lin9]] | |||
[[Category: Mmb]] | |||
[[Category: Muvb]] | |||
[[Category: Myb]] | |||
Revision as of 19:46, 19 September 2018
Crystal structure of B-Myb-LIN9-LIN52 complex
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