5uoe: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5uoe is ~~ON HOLD until Feb 01 2019~~

==Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)==

~~Authors~~: ~~Liang~~, W.G., ~~Bailey~~, L., ~~Kossiakoff, T~~., ~~Tang, W~~.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5uoe]] is a 15 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOE OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UOE FirstGlance].

~~Description~~: ~~Crystal Structure Analysis~~ of ~~Elbow~~-~~Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)~~

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uoe OCA], [http://pdbe.org/5uoe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uoe RCSB], [http://www.ebi.ac.uk/pdbsum/5uoe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uoe ProSAT]</td></tr>

[[Category: ~~Liang~~, ~~W.G~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Insulysin]]

[[Category: Bailey, L]]

[[Category: Kossiakoff, T]]

[[Category: ~~Bailey~~, L]]

[[Category: Liang, W G]]

[[Category: Tang, W.J]]

[[Category: Tang, W J]]

[[Category: Elbow-engineer]]

[[Category: Fab]]

[[Category: Hydrolase]]

[[Category: Hydrolase-immune system complex]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5uoe is ON HOLD  until Feb 01 2019
+==Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)==
+<StructureSection load='5uoe' size='340' side='right' caption='[[5uoe]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
-Authors: Liang, W.G., Bailey, L., Kossiakoff, T., Tang, W.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5uoe]] is a 15 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UOE FirstGlance]. <br>
-Description: Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uoe OCA], [http://pdbe.org/5uoe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uoe RCSB], [http://www.ebi.ac.uk/pdbsum/5uoe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uoe ProSAT]</span></td></tr>
-[[Category: Liang, W.G]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Insulysin]]
+[[Category: Bailey, L]]
 [[Category: Kossiakoff, T]]
-[[Category: Bailey, L]]
+[[Category: Liang, W G]]
-[[Category: Tang, W.J]]
+[[Category: Tang, W J]]
+[[Category: Elbow-engineer]]
+[[Category: Fab]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase-immune system complex]]