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==Crystal structure of human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the monobody YSX1==
==Crystal structure of human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the monobody YSX1==
<StructureSection load='6apx' size='340' side='right' caption='[[6apx]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
<StructureSection load='6apx' size='340' side='right'caption='[[6apx]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6apx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6APX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6APX FirstGlance]. <br>
<table><tr><td colspan='2'>[[6apx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6APX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6APX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.491&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUSP1, CL100, MKP1, PTPN10, VH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6apx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6apx OCA], [http://pdbe.org/6apx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6apx RCSB], [http://www.ebi.ac.uk/pdbsum/6apx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6apx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6apx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6apx OCA], [https://pdbe.org/6apx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6apx RCSB], [https://www.ebi.ac.uk/pdbsum/6apx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6apx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.  
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/DUS1_HUMAN DUS1_HUMAN] Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.[UniProtKB:P28563]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6apx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6apx" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
*[[Maltose-binding protein 3D structures|Maltose-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Escherichia coli K-12]]
[[Category: Synthetic construct sequences]]
[[Category: Homo sapiens]]
[[Category: Cherry, S]]
[[Category: Large Structures]]
[[Category: Gumpena, R]]
[[Category: Synthetic construct]]
[[Category: Lountos, G T]]
[[Category: Cherry S]]
[[Category: Sreejith, R K]]
[[Category: Gumpena R]]
[[Category: Tropea, J E]]
[[Category: Lountos GT]]
[[Category: Waugh, D S]]
[[Category: Sreejith RK]]
[[Category: C258]]
[[Category: Tropea JE]]
[[Category: Dual specificity phosphatase]]
[[Category: Waugh DS]]
[[Category: Dusp]]
[[Category: Hydrolase]]
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