5vyk: Difference between revisions
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==Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1== | |||
<StructureSection load='5vyk' size='340' side='right' caption='[[5vyk]], [[Resolution|resolution]] 1.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5vyk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VYK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vyk OCA], [http://pdbe.org/5vyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vyk RCSB], [http://www.ebi.ac.uk/pdbsum/5vyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vyk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/KSR1_HUMAN KSR1_HUMAN]] Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.[UniProtKB:Q61097] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Non-specific serine/threonine protein kinase]] | |||
[[Category: Jin, T]] | |||
[[Category: Kurinov, I]] | |||
[[Category: Lavoie, H]] | |||
[[Category: Maisonneuve, P]] | |||
[[Category: Marullo, S A]] | |||
[[Category: SIcheri, F]] | |||
[[Category: Sahmi, M]] | |||
[[Category: Therrien, M]] | |||
[[Category: Thevakumaran, N]] | |||
[[Category: Br]] | |||
[[Category: Braf]] | |||
[[Category: Cc-sam]] | |||
[[Category: Complex]] | |||
[[Category: Kinase]] | |||
[[Category: Ksr1]] | |||
[[Category: Pseudokinase]] | |||
[[Category: Signaling protein]] | |||
[[Category: Signaling]] | |||
Revision as of 06:28, 15 February 2018
Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1
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