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==Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7==
==Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7==
<StructureSection load='5t3p' size='340' side='right' caption='[[5t3p]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='5t3p' size='340' side='right'caption='[[5t3p]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5t3p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T3P FirstGlance]. <br>
<table><tr><td colspan='2'>[[5t3p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T3P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3p OCA], [http://pdbe.org/5t3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t3p RCSB], [http://www.ebi.ac.uk/pdbsum/5t3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3p OCA], [https://pdbe.org/5t3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t3p RCSB], [https://www.ebi.ac.uk/pdbsum/5t3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN]] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).  
[https://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Burgess-Brown, N]]
[[Category: Bountra C]]
[[Category: Delft, F von]]
[[Category: Burgess-Brown N]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Elkins, J M]]
[[Category: Elkins JM]]
[[Category: Huber, K]]
[[Category: Huber K]]
[[Category: Kopec, J]]
[[Category: Kopec J]]
[[Category: Mathea, S]]
[[Category: Mathea S]]
[[Category: Nunez, C A]]
[[Category: Nunez CA]]
[[Category: Siejka, P]]
[[Category: Siejka P]]
[[Category: Srikannathasan, V]]
[[Category: Srikannathasan V]]
[[Category: Tallant, C]]
[[Category: Tallant C]]
[[Category: Coa hydrolase]]
[[Category: Von Delft F]]
[[Category: Hydrolase]]
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