1n4n

Structure of the Plant Defensin PhD1 from Petunia Hybrida

spinqualitylabelsall models 1n4n, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1n4n is a 1 chain structure with sequence from Petunia x hybrida. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [DEF1_PETHY] Plant defense peptide with antifungal activity against F.oxysporum and B.cinerea. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The structure of a novel plant defensin isolated from the flowers of Petunia hybrida has been determined by (1)H NMR spectroscopy. P. hybrida defensin 1 (PhD1) is a basic, cysteine-rich, antifungal protein of 47 residues and is the first example of a new subclass of plant defensins with five disulfide bonds whose structure has been determined. PhD1 has the fold of the cysteine-stabilized alphabeta motif, consisting of an alpha-helix and a triple-stranded antiparallel beta-sheet, except that it contains a fifth disulfide bond from the first loop to the alpha-helix. The additional disulfide bond is accommodated in PhD1 without any alteration of its tertiary structure with respect to other plant defensins. Comparison of its structure with those of classic, four-disulfide defensins has allowed us to identify a previously unrecognized hydrogen bond network that is integral to structure stabilization in the family. Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds.,Janssen BJ, Schirra HJ, Lay FT, Anderson MA, Craik DJ Biochemistry. 2003 Jul 15;42(27):8214-22. PMID:12846570 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Plant defensin

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