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'''Unreleased structure'''


The entry 6ccw is ON HOLD
==Hybrid-2 form Human Telomeric G Quadruplex in Complex with Epiberberine==
<StructureSection load='6ccw' size='340' side='right' caption='[[6ccw]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ccw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CCW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EWV:Epiberberine'>EWV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ccw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ccw OCA], [http://pdbe.org/6ccw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ccw RCSB], [http://www.ebi.ac.uk/pdbsum/6ccw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ccw ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human telomeres can form DNA G-quadruplex (G4), an attractive target for anticancer drugs. Human telomeric G4s bear inherent structure polymorphism, challenging for understanding specific recognition by ligands or proteins. Protoberberines are medicinal natural-products known to stabilize telomeric G4s and inhibit telomerase. Here we report epiberberine (EPI) specifically recognizes the hybrid-2 telomeric G4 predominant in physiologically relevant K+ solution and converts other telomeric G4 forms to hybrid-2, the first such example. Our NMR structure in K+ solution shows EPI binding induces extensive rearrangement of the previously disordered 5' flanking and loop segments to form an unprecedented four-layer binding pocket specific to the hybrid-2 telomeric G4; EPI recruits the -1 adenine to form a "quasi-triad" intercalated between the external tetrad and a T:T:A triad, capped by a T:T base-pair. Our study provides structural basis for small-molecule drug design targeting the human telomeric G4.


Authors: Lin, C., Yang, D.Z.
Molecular Recognition of the Hybrid-2 Human Telomeric G-quadruplex by Epiberberine: Insights into Conversion of Telomeric G-quadruplex Structures.,Lin C, Wu G, Wang K, Onel B, Sakai S, Shao Y, Yang D Angew Chem Int Ed Engl. 2018 Jun 10. doi: 10.1002/anie.201804667. PMID:29888501<ref>PMID:29888501</ref>


Description: Hybrid-2 form Human Telomeric G Quadruplex in Complex with Epiberberine
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 6ccw" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lin, C]]
[[Category: Lin, C]]
[[Category: Yang, D.Z]]
[[Category: Yang, D Z]]
[[Category: Complex]]
[[Category: Dna]]
[[Category: G-quadruplex]]
[[Category: Telomere]]
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