6cdn: Difference between revisions
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==Crystal structure of cysteine-bound ferrous form of the crosslinked Cl-Tyr157 human cysteine dioxygenase== | |||
<StructureSection load='6cdn' size='340' side='right' caption='[[6cdn]], [[Resolution|resolution]] 2.06Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cdn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CDN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3CT:3-CHLORO-L-TYROSINE'>3CT</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_dioxygenase Cysteine dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.20 1.13.11.20] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cdn OCA], [http://pdbe.org/6cdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cdn RCSB], [http://www.ebi.ac.uk/pdbsum/6cdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cdn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CDO1_HUMAN CDO1_HUMAN]] Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cysteine dioxygenase]] | |||
[[Category: Li, J]] | [[Category: Li, J]] | ||
[[Category: Liu, A]] | [[Category: Liu, A]] | ||
[[Category: Shin, I]] | [[Category: Shin, I]] | ||
[[Category: Cys-tyr cofactor]] | |||
[[Category: Cysteine]] | |||
[[Category: Iron]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Unnatural amino acid]] | |||
