Progesterone receptor: Difference between revisions
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<StructureSection load=' | <StructureSection load='2w8y' size='350' side='right' caption='Structure of human progesterone receptor ligand-binding domain complex with RU486 (PDB entry [[2w8y]])' scene=''> | ||
== Function == | == Function == | ||
'''Progesterone receptor''' (PR) binds to DNA and inhibits transcription. The inhibition terminates when progesterone binds to PR. The ovarian steroid progesterone which is essential for breast development and reproductive behavior, is mediated by PR<ref>PMID:19072517</ref>. | |||
== Relevance == | == Relevance == | ||
The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy <ref>PMID:16234531</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the binding site and several PR-RU486 interactions<ref>PMID:19372222</ref>. | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of progesterone receptor == | == 3D Structures of progesterone receptor == | ||
