5qds: Difference between revisions
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==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000108a== | |||
<StructureSection load='5qds' size='340' side='right' caption='[[5qds]], [[Resolution|resolution]] 1.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qds]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QDS FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JGG:N-[(4-cyanophenyl)methyl]morpholine-4-carboxamide'>JGG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | ||
[[Category: Biel, J | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qds OCA], [http://pdbe.org/5qds PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qds RCSB], [http://www.ebi.ac.uk/pdbsum/5qds PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qds ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Protein-tyrosine-phosphatase]] | |||
[[Category: Biel, J T]] | |||
[[Category: Brandao-Neto, J]] | [[Category: Brandao-Neto, J]] | ||
[[Category: | [[Category: Delft, F von]] | ||
[[Category: | [[Category: Fraser, J S]] | ||
[[Category: Hill, Z | [[Category: Hill, Z B]] | ||
[[Category: Kang, E]] | [[Category: Kang, E]] | ||
[[Category: | [[Category: Keedy, D A]] | ||
[[Category: Rettenmaier, T J]] | |||
[[Category: Wells, J A]] | |||
[[Category: Allostery]] | |||
[[Category: Enzyme]] | |||
[[Category: Hydrolase]] | |||
[[Category: Multiconformer]] | |||
[[Category: Pandda]] | |||
[[Category: Protein tyrosine phosphatase]] | |||
[[Category: Protein tyrosine phosphatase 1b]] | |||
[[Category: Ptp]] | |||
[[Category: Ptp1b]] | |||
[[Category: Sgc - diamond i04-1 fragment screening]] | |||
Revision as of 07:48, 10 October 2018
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000108a
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