5zck: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5zck is ~~ON HOLD until Paper Publication~~

==Structure of the RIP3 core region==

~~Authors~~: Li, J., Wu, H.

== Structural highlights ==

<table><tr><td colspan='2'>[[5zck]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZCK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZCK FirstGlance]. <br>

~~Description: Structure of the RIP3 core region~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zck OCA], [http://pdbe.org/5zck PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zck RCSB], [http://www.ebi.ac.uk/pdbsum/5zck PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zck ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN]] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Li, J]]

[[Category: Wu, H]]

[[Category: Core region]]

[[Category: Protein fibril]]

[[Category: Rip3]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5zck is ON HOLD  until Paper Publication
+==Structure of the RIP3 core region==
+<StructureSection load='5zck' size='340' side='right' caption='[[5zck]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
-Authors: Li, J., Wu, H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5zck]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZCK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZCK FirstGlance]. <br>
-Description: Structure of the RIP3 core region
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zck OCA], [http://pdbe.org/5zck PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zck RCSB], [http://www.ebi.ac.uk/pdbsum/5zck PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zck ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN]] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Li, J]]
 [[Category: Wu, H]]
+[[Category: Core region]]
+[[Category: Protein fibril]]
+[[Category: Rip3]]