6fso: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6fso is ON HOLD until Paper Publication~~

==Crystal Structure of TGT in complex with methyl({[5-(pyridin-3-yloxy)furan-2-yl]methyl})amine==

~~Authors: Hassaan, E., Heine, A., Klebe, G.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6fso]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FSO OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FSO FirstGlance].

~~Description:~~ Crystal Structure of TGT in complex with methyl({[5-(pyridin-3-yloxy)furan-2-yl]methyl})amine

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=F63:N-METHYL-1-[5-(PYRIDIN-3-YLOXY)FURAN-2-YL]METHANAMINE'>F63</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fso OCA], [http://pdbe.org/6fso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fso RCSB], [http://www.ebi.ac.uk/pdbsum/6fso PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fso ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Hassaan, E]]

[[Category: Heine, A]]

~~[[Category: Hassaan, E]]~~

[[Category: Klebe, G]]

[[Category: Guanine exchange enzyme]]

[[Category: Protein interface]]

[[Category: Tgt]]

[[Category: Transferase]]

[[Category: Trna]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6fso is ON HOLD  until Paper Publication
+==Crystal Structure of TGT in complex with methyl({[5-(pyridin-3-yloxy)furan-2-yl]methyl})amine==
+<StructureSection load='6fso' size='340' side='right'caption='[[6fso]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
-Authors: Hassaan, E., Heine, A., Klebe, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6fso]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FSO FirstGlance]. <br>
-Description: Crystal Structure of TGT in complex with methyl({[5-(pyridin-3-yloxy)furan-2-yl]methyl})amine
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=F63:N-METHYL-1-[5-(PYRIDIN-3-YLOXY)FURAN-2-YL]METHANAMINE'>F63</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fso OCA], [http://pdbe.org/6fso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fso RCSB], [http://www.ebi.ac.uk/pdbsum/6fso PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fso ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Hassaan, E]]
 [[Category: Heine, A]]
-[[Category: Hassaan, E]]
 [[Category: Klebe, G]]
+[[Category: Guanine exchange enzyme]]
+[[Category: Protein interface]]
+[[Category: Tgt]]
+[[Category: Transferase]]
+[[Category: Trna]]