6fsy: Difference between revisions

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'''Unreleased structure'''


The entry 6fsy is ON HOLD
==Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand==
 
<StructureSection load='6fsy' size='340' side='right' caption='[[6fsy]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
Authors: Filippakopoulos, P., Picaud, S., Conway, S.J., Pike, A.C.W., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6fsy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FSY FirstGlance]. <br>
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E5Q:3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol'>E5Q</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fsy OCA], [http://pdbe.org/6fsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fsy RCSB], [http://www.ebi.ac.uk/pdbsum/6fsy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fsy ProSAT]</span></td></tr>
[[Category: Pike, A.C.W]]
</table>
[[Category: Arrowsmith, C.H]]
== Disease ==
[[Category: Von Delft, F]]
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
[[Category: Picaud, S]]
== Function ==
[[Category: Conway, S.J]]
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Conway, S J]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Filippakopoulos, P]]
[[Category: Filippakopoulos, P]]
[[Category: Edwards, A.M]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: Bountra, C]]
[[Category: Picaud, S]]
[[Category: Pike, A C.W]]
[[Category: Structural genomic]]
[[Category: Bromodomain]]
[[Category: Isoxazole]]
[[Category: Ligand]]
[[Category: Sgc]]
[[Category: Transcription]]
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