2f66: Difference between revisions
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'''Structure of the ESCRT-I endosomal trafficking complex''' | '''Structure of the ESCRT-I endosomal trafficking complex''' | ||
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[[Category: Kostelansky, M S.]] | [[Category: Kostelansky, M S.]] | ||
[[Category: Lee, S.]] | [[Category: Lee, S.]] | ||
[[Category: | [[Category: Endosomal sorting complex required for transport]] | ||
[[Category: | [[Category: Endosome]] | ||
[[Category: | [[Category: Escrt protein complex]] | ||
[[Category: | [[Category: Escrt-i]] | ||
[[Category: | [[Category: Trafficking complex]] | ||
[[Category: | [[Category: Tsg101]] | ||
[[Category: | [[Category: Ubiquitin]] | ||
[[Category: | [[Category: Vacuolar protein sorting]] | ||
[[Category: | [[Category: Vps23]] | ||
[[Category: | [[Category: Vps28]] | ||
[[Category: | [[Category: Vps37]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:30:26 2008'' | |||
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Revision as of 00:30, 4 May 2008
Structure of the ESCRT-I endosomal trafficking complex
Overview
The endosomal sorting complex required for transport (ESCRT) complexes are central to receptor downregulation, lysosome biogenesis, and budding of HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The crystal structures of a Vps23:Vps28 core subcomplex and the Vps23:Vps28:Vps37 core were solved at 2.1 and 2.8 A resolution. Each subunit contains a structurally similar pair of helices that form the core. The N-terminal domain of Vps28 has a hydrophobic binding site on its surface that is conformationally dynamic. The C-terminal domain of Vps28 binds the ESCRT-II complex. The structure shows how ESCRT-I is assembled by a compact core from which the Vps23 UEV domain, the Vps28 C domain, and other domains project to bind their partners.
About this Structure
2F66 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Structural and functional organization of the ESCRT-I trafficking complex., Kostelansky MS, Sun J, Lee S, Kim J, Ghirlando R, Hierro A, Emr SD, Hurley JH, Cell. 2006 Apr 7;125(1):113-26. PMID:16615894 Page seeded by OCA on Sun May 4 03:30:26 2008
