6ckn: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6ckn is ~~ON HOLD~~

==Crystal structure of an AF10 fragment==

~~Authors~~: ~~Qin~~, S., ~~Tempel~~, W., Li, Y.~~, Bountra, C~~.~~, Arrowsmith, C~~.H.~~, Edwards,~~ A.M.~~, Min, J~~.~~, Structural Genomics Consortium~~ (~~SGC~~)

== Structural highlights ==

<table><tr><td colspan='2'>[[6ckn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKN OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKN FirstGlance].

~~Description~~: ~~Crystal structure of an AF10 fragment~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

[[Category: ~~Arrowsmith~~, C.H]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ckn OCA], [http://pdbe.org/6ckn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ckn RCSB], [http://www.ebi.ac.uk/pdbsum/6ckn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ckn ProSAT]</td></tr>

[[Category: ~~Qin~~, S]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN]] Precursor T-cell acute lymphoblastic leukemia. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.

== Function ==

[[http://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN]] Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.<ref>PMID:17868029</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Edwards, A M]]

[[Category: Li, Y]]

[[Category: Min, J]]

[[Category: ~~Edwards~~, ~~A.M~~]]

[[Category: Qin, S]]

[[Category: Structural ~~Genomics Consortium (Sgc)]]~~

[[Category: Structural genomic]]

~~[[Category: Bountra, C~~]]

[[Category: Tempel, W]]

[[Category: Dna binding protein]]

[[Category: Sgc]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ckn is ON HOLD
+==Crystal structure of an AF10 fragment==
+<StructureSection load='6ckn' size='340' side='right' caption='[[6ckn]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
-Authors: Qin, S., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ckn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKN FirstGlance]. <br>
-Description: Crystal structure of an AF10 fragment
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-[[Category: Arrowsmith, C.H]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ckn OCA], [http://pdbe.org/6ckn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ckn RCSB], [http://www.ebi.ac.uk/pdbsum/6ckn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ckn ProSAT]</span></td></tr>
-[[Category: Qin, S]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN]] Precursor T-cell acute lymphoblastic leukemia. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.  A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.
+== Function ==
+[[http://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN]] Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.<ref>PMID:17868029</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Edwards, A M]]
 [[Category: Li, Y]]
 [[Category: Min, J]]
-[[Category: Edwards, A.M]]
+[[Category: Qin, S]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Structural genomic]]
-[[Category: Bountra, C]]
 [[Category: Tempel, W]]
+[[Category: Dna binding protein]]
+[[Category: Sgc]]