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==Structure of Mnk1 in complex with DS12881479==
==Structure of Mnk1 in complex with DS12881479==
<StructureSection load='5wvd' size='340' side='right' caption='[[5wvd]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5wvd' size='340' side='right'caption='[[5wvd]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5wvd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WVD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WVD FirstGlance]. <br>
<table><tr><td colspan='2'>[[5wvd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WVD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7UX:1-methyl-N-(5-phenyl-1,3-thiazol-2-yl)piperidine-4-carboxamide'>7UX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wvj|5wvj]], [[5wvl|5wvl]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7UX:1-methyl-N-(5-phenyl-1,3-thiazol-2-yl)piperidine-4-carboxamide'>7UX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MKNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wvd OCA], [https://pdbe.org/5wvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wvd RCSB], [https://www.ebi.ac.uk/pdbsum/5wvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wvd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wvd OCA], [http://pdbe.org/5wvd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wvd RCSB], [http://www.ebi.ac.uk/pdbsum/5wvd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wvd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MKNK1_HUMAN MKNK1_HUMAN] May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.<ref>PMID:9155018</ref> <ref>PMID:11463832</ref> <ref>PMID:15350534</ref> <ref>PMID:9878069</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wvd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wvd" style="background-color:#fffaf0;"></div>
==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Hanzawa, H]]
[[Category: Large Structures]]
[[Category: Matsui, Y]]
[[Category: Hanzawa H]]
[[Category: Inactive conformation]]
[[Category: Matsui Y]]
[[Category: Kinase]]
[[Category: Kinase inhibitor]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/5wvd"