Pho4: Difference between revisions
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Its structure is a basic basic helix-loop-helix (bHLH)<ref>PMID:2220078</ref> | Its structure is a basic basic helix-loop-helix (bHLH)<ref>PMID:2220078</ref> | ||
The pho4 protein takes part in transcription of several yeast genes related to phosphate metabolism: | The pho4 protein takes part in transcription of several yeast genes related to phosphate metabolism: | ||
PH084 | [[PH05]] encoding repressible acid phosphatase | ||
[[PH08]] encoding alkaline phosphatase<ref>PMID:2671650</ref> | |||
[[PH081 ]] a regulatory gene<ref>PMID:2671650</ref> | |||
[[PH084]] phosphate permease gene<ref>PMID:3902805</ref> | |||
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The structure of the Pho4 protein is a basic Helix-loop-helix(bHLH) , The linker sequence between Helix1(H1) and Helix2(H2) contains several residues: Asn, Glu, Pro and Ser<ref>PMID: 3775366</ref> . The DNA binding site is a homodimer and two monomers in a left‐handed four‐helix bundle fold (identical to bHLH/Zip and bHLH proteins fold) . | The structure of the Pho4 protein is a basic Helix-loop-helix(bHLH) , The linker sequence between Helix1(H1) and Helix2(H2) contains several residues: Asn, Glu, Pro and Ser<ref>PMID: 3775366</ref> . The DNA binding site is a homodimer and two monomers in a left‐handed four‐helix bundle fold (identical to bHLH/Zip and bHLH proteins fold) . | ||
[loop structure] | |||
Pho4 loops (conserved structure?) are long but compact and forms a short alpha-helical structure <ref>PMID:1170095</ref>. The PHO4 loop contains a Trp residue that faces the aromatic rings of Tyr52 and His55 of helix H2, and Pro28 of H2 and H1.an aromatic cluster forms a cap structure is observed.<ref>PMID: 9303313</ref> | Pho4 loops (conserved structure?) are long but compact and forms a short alpha-helical structure <ref>PMID:1170095</ref>. The PHO4 loop contains a Trp residue that faces the aromatic rings of Tyr52 and His55 of helix H2, and Pro28 of H2 and H1.an aromatic cluster forms a cap structure is observed.<ref>PMID: 9303313</ref> | ||
