Pho4: Difference between revisions
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The pho4 protein takes part in transcription of several yeast genes related to phosphate metabolism: | The pho4 protein takes part in transcription of several yeast genes related to phosphate metabolism: | ||
[[PH05]] encoding repressible acid phosphatase, | '''[[PH05]] encoding repressible acid phosphatase,''' the expression of Pho5 in Saccharomyces cerevisiae is derepressed by a specific level of inorganic phosphate (Pi), and depressed when the Pi concentrate in the medium is lowered, the regulatory system of the Pi signals coded by PHO4 PHO2 , PHO80, and PHO81 genes.<ref>PMID:2671650</ref> | ||
[[PH08]] encoding alkaline phosphatase<ref>PMID:2671650</ref> | '''[[PH08]] encoding alkaline phosphatase'''<ref>PMID:2671650</ref> | ||
[[PH081 ]] a regulatory gene<ref>PMID:2671650</ref> | '''[[PH081 ]] a regulatory gene''' regulated by PHO system wuth the use of Pi<ref>PMID:2671650</ref> | ||
[[PH084]] phosphate permease gene<ref>PMID:3902805</ref> | '''[[PH084]] phosphate permease gene'''<ref>PMID:3902805</ref> | ||
other than that, the Pho4 protein seems to contain a coding region for non translated mitochondrial proteins<ref>PMID:2183025</ref> | other than that, the Pho4 protein seems to contain a coding region for non translated mitochondrial proteins<ref>PMID:2183025</ref> | ||
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==sturcture== | ==sturcture== | ||
The structure of the Pho4 protein is a basic Helix-loop-helix(bHLH) , The linker sequence between Helix1(H1) and Helix2(H2) contains several residues: Asn, Glu, Pro and Ser<ref>PMID:3775366</ref>. The DNA binding site is a homodimer and two monomers in a left‐handed four‐helix bundle fold (identical to bHLH/Zip and bHLH proteins fold) . | The structure of the Pho4 protein is a basic Helix-loop-helix(bHLH), The linker sequence between Helix1(H1) and Helix2(H2) contains several residues: Asn, Glu, Pro and Ser<ref>PMID:3775366</ref>. The DNA binding site is a homodimer and two monomers in a left‐handed four‐helix bundle fold (identical to bHLH/Zip and bHLH proteins fold) . | ||
*loop structure | *loop structure | ||
