5ov3: Difference between revisions
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==Structure of the RbBP5 beta-propeller domain== | |||
<StructureSection load='5ov3' size='340' side='right' caption='[[5ov3]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ov3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OV3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ov3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ov3 OCA], [http://pdbe.org/5ov3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ov3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ov3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ov3 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gamblin, S J]] | |||
[[Category: Mittal, A]] | |||
[[Category: Wilson, J R]] | |||
[[Category: Zhang, Y]] | |||
[[Category: Structural protein]] | |||
[[Category: Wd40 beta-propeller]] | |||
Revision as of 06:30, 28 March 2018
Structure of the RbBP5 beta-propeller domain
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