5zfa: Difference between revisions
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==Structure of human dihydroorotate dehydrogenase in complex with 287-12-OCOiPr== | |||
<StructureSection load='5zfa' size='340' side='right' caption='[[5zfa]], [[Resolution|resolution]] 1.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5zfa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZFA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9BU:(2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,6-dimethylocta-2,6-dien-1-yl+2-methylpropanoate'>9BU</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zfa OCA], [http://pdbe.org/5zfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zfa RCSB], [http://www.ebi.ac.uk/pdbsum/5zfa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zfa ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Amalia, E]] | |||
[[Category: Harada, S]] | |||
[[Category: Inaoka, K D]] | |||
[[Category: Kido, Y]] | |||
[[Category: Kita, K]] | |||
[[Category: Miyazaki, Y]] | |||
[[Category: Moore, L A]] | |||
[[Category: Nakamura, M]] | [[Category: Nakamura, M]] | ||
[[Category: Saimoto, H]] | |||
[[Category: Sakai, C]] | [[Category: Sakai, C]] | ||
[[Category: Shiba, T]] | [[Category: Shiba, T]] | ||
[[Category: | [[Category: Dihydroorotate/orotate]] | ||
[[Category: | [[Category: Inhibitor complex]] | ||
[[Category: | [[Category: Mitochondrial inner membrane]] | ||
[[Category: | [[Category: Oxidoreductase]] | ||
[[Category: | [[Category: Rossmann fold]] | ||
[[Category: Ubiquinone/ubiquinol]] | |||
Revision as of 07:57, 26 September 2018
Structure of human dihydroorotate dehydrogenase in complex with 287-12-OCOiPr
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