6fy5: Difference between revisions
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==Crystal structure of the macro domain of human macroh2a2== | |||
<StructureSection load='6fy5' size='340' side='right' caption='[[6fy5]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6fy5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FY5 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zr3|1zr3]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fy5 OCA], [http://pdbe.org/6fy5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fy5 RCSB], [http://www.ebi.ac.uk/pdbsum/6fy5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fy5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/H2AW_HUMAN H2AW_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.<ref>PMID:15621527</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hothorn, M]] | [[Category: Hothorn, M]] | ||
[[Category: Dna binding protein]] | |||
[[Category: Histone variant]] | |||
[[Category: Macro domain]] | |||
Revision as of 06:04, 4 April 2018
Crystal structure of the macro domain of human macroh2a2
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