5ud8: Difference between revisions
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==Crystal Structure of Mutant Ig-like Domain== | |||
<StructureSection load='5ud8' size='340' side='right' caption='[[5ud8]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ud8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UD8 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ud7|5ud7]]</td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ud8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ud8 OCA], [http://pdbe.org/5ud8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ud8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ud8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ud8 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/TREM2_HUMAN TREM2_HUMAN]] Progressive non-fluent aphasia;Amyotrophic lateral sclerosis;Nasu-Hakola disease;Semantic dementia;Behavioral variant of frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TREM2_HUMAN TREM2_HUMAN]] May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.<ref>PMID:10799849</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Min, X]] | [[Category: Min, X]] | ||
[[Category: Sudom, A]] | [[Category: Sudom, A]] | ||
[[Category: Wang, Z]] | [[Category: Wang, Z]] | ||
[[Category: Ig-like domain]] | |||
[[Category: Immune system]] | |||
Revision as of 05:52, 4 April 2018
Crystal Structure of Mutant Ig-like Domain
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