5zjv: Difference between revisions
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==Crystal structure of the catalytic domain of MCR-1 (cMCR-1) in complex with xylose== | |||
<StructureSection load='5zjv' size='340' side='right' caption='[[5zjv]], [[Resolution|resolution]] 1.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5zjv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZJV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LXC:BETA-L-XYLOPYRANOSE'>LXC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zjv OCA], [http://pdbe.org/5zjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zjv RCSB], [http://www.ebi.ac.uk/pdbsum/5zjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zjv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MCR1_ECOLX MCR1_ECOLX]] Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).<ref>PMID:26603172</ref> Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).<ref>PMID:26603172</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Han, Z]] | |||
[[Category: Liu, Z X]] | |||
[[Category: Wen, G]] | |||
[[Category: Yu, X L]] | |||
[[Category: Zeng, C]] | [[Category: Zeng, C]] | ||
[[Category: | [[Category: Colistin resistance]] | ||
[[Category: | [[Category: Complex]] | ||
[[Category: | [[Category: Mcr-1]] | ||
[[Category: | [[Category: Structural protein]] | ||
[[Category: Transferase]] | |||
[[Category: Xylose]] | |||
Revision as of 05:32, 25 April 2018
Crystal structure of the catalytic domain of MCR-1 (cMCR-1) in complex with xylose
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