6cmy: Difference between revisions
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==Solution NMR Structure Determination of Mouse Melanoregulin== | |||
<StructureSection load='6cmy' size='340' side='right' caption='[[6cmy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cmy]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5kbo 5kbo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CMY FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cmy OCA], [http://pdbe.org/6cmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cmy RCSB], [http://www.ebi.ac.uk/pdbsum/6cmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cmy ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MREG_MOUSE MREG_MOUSE]] Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells.<ref>PMID:15550542</ref> <ref>PMID:17260955</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Melanoregulin (Mreg) is a small, highly charged, multiply palmitoylated protein present on the membrane of melanosomes. Mreg is implicated in the transfer of melanosomes from melanocytes to keratinocytes, and in promoting the microtubule minus end-directed transport of these organelles. The possible molecular function of Mreg was identified by solving its structure using nuclear magnetic resonance (NMR) spectroscopy. Mreg contains six alpha helices forming a fishhook-like fold in which positive and negative charges occupy opposite sides of the protein's surface and sandwich a putative, cholesterol recognition sequence (CRAC motif). Mreg containing a point mutation within its CRAC motif still targets to late endosomes/lysosomes, but no longer promotes their microtubule minus end-directed transport. Moreover, wild-type Mreg does not promote the microtubule minus end-directed transport of late endosomes/lysosomes in cells transiently depleted of cholesterol. Finally, reversing the charge of three clustered acidic residues partially inhibits Mreg's ability to drive these organelles to microtubule minus ends. | |||
The Structure of Melanoregulin Reveals a Role for Cholesterol Recognition in the Protein's Ability to Promote Dynein Function.,Rout AK, Wu X, Starich MR, Strub MP, Hammer JA, Tjandra N Structure. 2018 Aug 8. pii: S0969-2126(18)30255-7. doi:, 10.1016/j.str.2018.07.009. PMID:30174147<ref>PMID:30174147</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6cmy" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: III, J A.Hammer]] | |||
[[Category: Rout, A K]] | |||
[[Category: Starich, M R]] | |||
[[Category: Strub, M P]] | |||
[[Category: Tjandra, N]] | |||
[[Category: Wu, X]] | [[Category: Wu, X]] | ||
[[Category: | [[Category: Alpha helical]] | ||
[[Category: | [[Category: Cellular pigementation]] | ||
[[Category: | [[Category: Crac motif]] | ||
[[Category: | [[Category: Dilute suppressor locus]] | ||
[[Category: | [[Category: Lipid binding protein]] | ||
[[Category: Melanosome transport]] | |||
