2gal: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2gal.gif|left|200px]] | [[Image:2gal.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_2gal", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
| | or leave the SCENE parameter empty for the default display. | ||
| | --> | ||
{{STRUCTURE_2gal| PDB=2gal | SCENE= }} | |||
}} | |||
'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE''' | '''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE''' | ||
| Line 27: | Line 24: | ||
[[Category: Acharya, K R.]] | [[Category: Acharya, K R.]] | ||
[[Category: Leonidas, D D.]] | [[Category: Leonidas, D D.]] | ||
[[Category: | [[Category: Carbohydrate binding]] | ||
[[Category: | [[Category: Galaptin]] | ||
[[Category: | [[Category: Galectin]] | ||
[[Category: | [[Category: Lectin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:53:23 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 01:53, 4 May 2008
CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE
Overview
Knowledge about carbohydrate recognition domains of galectins, formerly known as S-type animal lectins, is important in understanding their role(s) in cell-cell interactions. Here we report the crystal structure of human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This is the first structure of a galectin determined in both free and carbohydrate-bound forms. The structure shows a fold similar to that of the prototype galectins -1 and -2, but has greater similarity to a related galectin molecule, Gal-10. Even though the carbohydrate-binding residues are conserved, there are significant changes in this pocket due to shortening of a loop structure. The monomeric hGal-7 molecule exists as a dimer in the crystals, but adopts a packing arrangement considerably different from that of Gal-1 and Gal-2, which has implications for carbohydrate recognition.
About this Structure
2GAL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:9760227 Page seeded by OCA on Sun May 4 04:53:23 2008
