Vpr protein: Difference between revisions

Line 4:

'''Vpr protein''' (Vpr) or '''viral protein R''' is a 96 amino acid protein which encoded by the human Immunodeﬁciency virus type 1 ([[HIV-1]]). Vpr has several roles in the progression of acquired immunodeficiency syndrome ({{Wikipedia|AIDS}}) disease, including regulation the HIV-1 pre-integration complex ({{Wikipedia|Pre-integration_complex}}) nuclear import and virus replication in non-dividing macrophages<ref>PMID:12614620</ref>. Moreover, Vpr prevents mitosis of dividing infect cells by blockade at G2 phase, when the viral promoter is more active, and induced apoptosis of these cells in G1 and M phase. Both the activities of cell cycle arrest and induce apoptosis has proven to be independence by mutations that can cause only one of these affects<ref>PMID:28075409</ref>.

For details see [[HIV and accessory proteins]].

For details about another HIV-1 components and its replication pathway see [[HIV and accessory proteins]].

Vpr protein: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

Revision as of 13:42, 3 April 2018 view source Elia Shlush (talk \| contribs) 41 edits No edit summary ← Older edit		Revision as of 19:13, 3 April 2018 view source Elia Shlush (talk \| contribs) 41 edits No edit summary Newer edit →
Line 4:		Line 4:
	'''Vpr protein''' (Vpr) or '''viral protein R''' is a 96 amino acid protein which encoded by the human Immunodeﬁciency virus type 1 ([[HIV-1]]). Vpr has several roles in the progression of acquired immunodeficiency syndrome ({{Wikipedia\|AIDS}}) disease, including regulation the HIV-1 pre-integration complex ({{Wikipedia\|Pre-integration_complex}}) nuclear import and virus replication in non-dividing macrophages<ref>PMID:12614620</ref>. Moreover, Vpr prevents mitosis of dividing infect cells by blockade at G2 phase, when the viral promoter is more active, and induced apoptosis of these cells in G1 and M phase. Both the activities of cell cycle arrest and induce apoptosis has proven to be independence by mutations that can cause only one of these affects<ref>PMID:28075409</ref>.		'''Vpr protein''' (Vpr) or '''viral protein R''' is a 96 amino acid protein which encoded by the human Immunodeﬁciency virus type 1 ([[HIV-1]]). Vpr has several roles in the progression of acquired immunodeficiency syndrome ({{Wikipedia\|AIDS}}) disease, including regulation the HIV-1 pre-integration complex ({{Wikipedia\|Pre-integration_complex}}) nuclear import and virus replication in non-dividing macrophages<ref>PMID:12614620</ref>. Moreover, Vpr prevents mitosis of dividing infect cells by blockade at G2 phase, when the viral promoter is more active, and induced apoptosis of these cells in G1 and M phase. Both the activities of cell cycle arrest and induce apoptosis has proven to be independence by mutations that can cause only one of these affects<ref>PMID:28075409</ref>.

	For details see [[HIV and accessory proteins]].		For details about another HIV-1 components and its replication pathway see [[HIV and accessory proteins]].