Vpr protein: Difference between revisions

From Proteopedia
Jump to navigationJump to search
No edit summary
No edit summary
Line 6: Line 6:
For details about another HIV-1 components and its replication pathway see [[HIV and accessory proteins]].
For details about another HIV-1 components and its replication pathway see [[HIV and accessory proteins]].


== Conservation ==
Vpr is highly conserved in HIV and  simian immunodeficiency virus (SIV) {{Wikipedia|Simian_immunodeficiency_virus}}, similar retrovirus which infects non-human primates<ref>PMID:12614620</ref>. In addition, all primate lentiviruses {{Wikipedia|Lentivirus}} has vpr gene whose protein product has highly conserved motifs. HIV-2 and SIVsm lentiviruses have additionally gene - vpx. In these lentiviruses, vpr and vpx executes together the roles which HIV-1 vpr perform. Vpr and Vpx has low conservation between them.