6cgd: Difference between revisions
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==Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and Amikacin== | |||
<StructureSection load='6cgd' size='340' side='right' caption='[[6cgd]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cgd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CGD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CGD FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKN:(2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide'>AKN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6c5u|6c5u]], [[6cav|6cav]], [[6cey|6cey]]</td></tr> | ||
[[Category: Caldwell, S | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cgd OCA], [http://pdbe.org/6cgd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cgd RCSB], [http://www.ebi.ac.uk/pdbsum/6cgd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cgd ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/AACA_STAAU AACA_STAAU]] Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Berghuis, A M]] | |||
[[Category: Caldwell, S J]] | |||
[[Category: Aminoglycoside]] | |||
[[Category: Antibiotic]] | |||
[[Category: Kinase]] | |||
[[Category: Resistance]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-antibiotic complex]] | |||
Revision as of 13:52, 11 April 2018
Aminoglycoside Phosphotransferase (2)-Ia in complex with GMPPNP, Magnesium, and Amikacin
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