6g40: Difference between revisions
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==Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH9525== | |||
<StructureSection load='6g40' size='340' side='right'caption='[[6g40]], [[Resolution|resolution]] 2.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g40]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G40 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ELK:~{N}-(3-methoxy-4-methyl-phenyl)-4-(4-methoxy-2-oxidanylidene-3~{H}-benzimidazol-1-yl)piperidine-1-carboxamide'>ELK</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g40 OCA], [http://pdbe.org/6g40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g40 RCSB], [http://www.ebi.ac.uk/pdbsum/6g40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g40 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/OGG1_MOUSE OGG1_MOUSE]] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Helleday, T]] | |||
[[Category: Masuyer, G]] | |||
[[Category: Stenmark, P]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Dna lyase]] | |||
[[Category: N-glycosylase]] | |||
Revision as of 07:16, 10 April 2019
Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH9525
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