6g4q: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
m Protected "6g4q" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 6g4q is ON HOLD  until Paper Publication
==Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2==
 
<StructureSection load='6g4q' size='340' side='right' caption='[[6g4q]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
Authors: Bailey, H.J., Shrestha, L., Rembeza, E., Sorrell, F.J., Strain-Damerell, C., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6g4q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G4Q FirstGlance]. <br>
Description: Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NEP:N1-PHOSPHONOHISTIDINE'>NEP</scene></td></tr>
[[Category: Bailey, H.J]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate--CoA_ligase_(ADP-forming) Succinate--CoA ligase (ADP-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.2.1.5 6.2.1.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g4q OCA], [http://pdbe.org/6g4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g4q RCSB], [http://www.ebi.ac.uk/pdbsum/6g4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g4q ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/SUCA_HUMAN SUCA_HUMAN]] Fatal infantile lactic acidosis with methylmalonic aciduria. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/SUCB1_HUMAN SUCB1_HUMAN]] Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria. The disease is caused by mutations affecting the gene represented in this entry.  
== Function ==
[[http://www.uniprot.org/uniprot/SUCA_HUMAN SUCA_HUMAN]] Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.[HAMAP-Rule:MF_03222] [[http://www.uniprot.org/uniprot/SUCB1_HUMAN SUCB1_HUMAN]] ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity).[HAMAP-Rule:MF_03220]<ref>PMID:15877282</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C]]
[[Category: Bailey, H J]]
[[Category: Bountra, C]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown, N]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Newman, J]]
[[Category: Rembeza, E]]
[[Category: Shrestha, L]]
[[Category: Shrestha, L]]
[[Category: Edwards, A]]
[[Category: Sorrell, F J]]
[[Category: Strain-Damerell, C]]
[[Category: Strain-Damerell, C]]
[[Category: Yue, W.W]]
[[Category: Yue, W W]]
[[Category: Rembeza, E]]
[[Category: Atp-specific]]
[[Category: Bountra, C]]
[[Category: Complex]]
[[Category: Arrowsmith, C]]
[[Category: Ligase]]
[[Category: Sorrell, F.J]]
[[Category: Mitochondrial]]
[[Category: Succinyl-coa ligase]]
Retrieved from "https://proteopedia.org/6g4q"