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[[Image:2gic.gif|left|200px]]
[[Image:2gic.gif|left|200px]]


{{Structure
<!--
|PDB= 2gic |SIZE=350|CAPTION= <scene name='initialview01'>2gic</scene>, resolution 2.920&Aring;
The line below this paragraph, containing "STRUCTURE_2gic", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=IUM:URANYL+(VI)+ION'>IUM</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE= N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11277 Vesicular stomatitis Indiana virus])
-->
|DOMAIN=
{{STRUCTURE_2gic| PDB=2gic  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gic OCA], [http://www.ebi.ac.uk/pdbsum/2gic PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gic RCSB]</span>
}}


'''Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex'''
'''Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex'''
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[[Category: Wertz, G W.]]
[[Category: Wertz, G W.]]
[[Category: Zhang, X.]]
[[Category: Zhang, X.]]
[[Category: negative strand virus]]
[[Category: Negative strand virus]]
[[Category: nucleocapsid]]
[[Category: Nucleocapsid]]
[[Category: protein-rna complex]]
[[Category: Protein-rna complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:08:24 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:16:59 2008''

Revision as of 02:08, 4 May 2008

File:2gic.gif

Template:STRUCTURE 2gic

Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex


Overview

Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.

About this Structure

2GIC is a Single protein structure of sequence from Vesicular stomatitis indiana virus. Full crystallographic information is available from OCA.

Reference

Structure of the vesicular stomatitis virus nucleoprotein-RNA complex., Green TJ, Zhang X, Wertz GW, Luo M, Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15. PMID:16778022 Page seeded by OCA on Sun May 4 05:08:24 2008

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