6cl1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6cl1 ~~is ON HOLD~~ ~~until Paper Publication~~

==Caspase-7 in complex with Ac-DW3-KE==

~~Authors~~: ~~Solania, A~~.T.~~, Gonzalez~~-~~Paez, G~~.E.~~, Wolan, D~~.W.

== Structural highlights ==

<table><tr><td colspan='2'>[[6cl1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CL1 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CL1 FirstGlance].

~~Description~~: Caspase-7 ~~in complex~~ with Ac-~~DW3~~-KE

</td></tr><tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=B3L:(3S)-3-AMINO-5-METHYLHEXANOIC+ACID'>B3L</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </td></tr>

[[Category: ~~Wolan, D.W~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cl1 OCA], [http://pdbe.org/6cl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cl1 RCSB], [http://www.ebi.ac.uk/pdbsum/6cl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cl1 ProSAT]</td></tr>

[[Category: Gonzalez-Paez, G.E]]

</table>

[[Category: Solania, A.T]]

== Function ==

[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

__TOC__

</StructureSection>

[[Category: Caspase-7]]

[[Category: Gonzalez-Paez, G E]]

[[Category: Solania, A T]]

[[Category: Wolan, D W]]

[[Category: Apoptosis]]

[[Category: Caspase-3]]

[[Category: Hydrolase]]

[[Category: Inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6cl1 is ON HOLD  until Paper Publication
+==Caspase-7 in complex with Ac-DW3-KE==
+<StructureSection load='6cl1' size='340' side='right'  caption='[[6cl1]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-Authors: Solania, A.T., Gonzalez-Paez, G.E., Wolan, D.W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6cl1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CL1 FirstGlance]. <br>
-Description: Caspase-7 in complex with Ac-DW3-KE
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=B3L:(3S)-3-AMINO-5-METHYLHEXANOIC+ACID'>B3L</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
-[[Category: Wolan, D.W]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cl1 OCA], [http://pdbe.org/6cl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cl1 RCSB], [http://www.ebi.ac.uk/pdbsum/6cl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cl1 ProSAT]</span></td></tr>
-[[Category: Gonzalez-Paez, G.E]]
+</table>
-[[Category: Solania, A.T]]
+== Function ==
+[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
+__TOC__
+</StructureSection>
+[[Category: Caspase-7]]
+[[Category: Gonzalez-Paez, G E]]
+[[Category: Solania, A T]]
+[[Category: Wolan, D W]]
+[[Category: Apoptosis]]
+[[Category: Caspase-3]]
+[[Category: Hydrolase]]
+[[Category: Inhibitor]]