6g3v: Difference between revisions
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==Crystal structure of human carbonic anhydrase I in complex with the inhibitor famotidine== | |||
<StructureSection load='6g3v' size='340' side='right' caption='[[6g3v]], [[Resolution|resolution]] 1.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g3v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G3V FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FO9:famotidine'>FO9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g3v OCA], [http://pdbe.org/6g3v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g3v RCSB], [http://www.ebi.ac.uk/pdbsum/6g3v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g3v ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CAH1_HUMAN CAH1_HUMAN]] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.<ref>PMID:10550681</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Famotidine, an antiulcer drug incorporating a sulfamide motif, was investigated as carbonic anhydrase inhibitor (CAI). It acts as a nanomolar inhibitor of several human (hCA II, VI, VII and XII) and Helicobacter pylori CAs. The high resolution X-ray structures of famotidine bound to hCA I and II revealed interesting aspects related to its CA inhibition mechanism, offering the possibility to develop antibacterials with a novel mechanism of action. | |||
Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases.,Angeli A, Ferraroni M, Supuran CT ACS Med Chem Lett. 2018 Sep 4;9(10):1035-1038. doi:, 10.1021/acsmedchemlett.8b00334. eCollection 2018 Oct 11. PMID:30344913<ref>PMID:30344913</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6g3v" style="background-color:#fffaf0;"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Carbonate dehydratase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Angeli, A]] | |||
[[Category: Ferraroni, M]] | [[Category: Ferraroni, M]] | ||
[[Category: | [[Category: Supuran, C T]] | ||
[[Category: Lyase]] | |||
Latest revision as of 20:31, 2 December 2018
Crystal structure of human carbonic anhydrase I in complex with the inhibitor famotidine
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