6g5g: Difference between revisions
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==Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 2== | |||
<StructureSection load='6g5g' size='340' side='right' caption='[[6g5g]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g5g]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G5G FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g5g OCA], [http://pdbe.org/6g5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g5g RCSB], [http://www.ebi.ac.uk/pdbsum/6g5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g5g ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bontoxilysin]] | |||
[[Category: Beard, M]] | |||
[[Category: Carre, D]] | |||
[[Category: Dong, M]] | |||
[[Category: Elliot, M]] | |||
[[Category: Favre-Guilmard, C]] | |||
[[Category: Kalinichev, M]] | |||
[[Category: Krupp, J]] | |||
[[Category: Lezmi, S]] | |||
[[Category: Liu, S M]] | |||
[[Category: Maignel, J]] | |||
[[Category: Masuyer, G]] | |||
[[Category: Mir, I]] | |||
[[Category: Nicoleau, C]] | |||
[[Category: Palan, S]] | |||
[[Category: Perier, C]] | |||
[[Category: Raban, E]] | |||
[[Category: Stenmark, P]] | |||
[[Category: Botulinum toxin]] | |||
[[Category: Neurotoxin]] | |||
[[Category: Protein engineering]] | |||
[[Category: Receptor binding]] | |||
[[Category: Toxin]] | |||
