2gu8: Difference between revisions

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[[Image:2gu8.jpg|left|200px]]
[[Image:2gu8.jpg|left|200px]]


{{Structure
<!--
|PDB= 2gu8 |SIZE=350|CAPTION= <scene name='initialview01'>2gu8</scene>, resolution 2.20&Aring;
The line below this paragraph, containing "STRUCTURE_2gu8", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND= <scene name='pdbligand=796:N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE'>796</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_2gu8| PDB=2gu8  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gu8 OCA], [http://www.ebi.ac.uk/pdbsum/2gu8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gu8 RCSB]</span>
}}


'''Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies'''
'''Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies'''
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==About this Structure==
==About this Structure==
2GU8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GU8 OCA].  
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GU8 OCA].  


==Reference==
==Reference==
Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies., Lin X, Murray JM, Rico AC, Wang MX, Chu DT, Zhou Y, Del Rosario M, Kaufman S, Ma S, Fang E, Crawford K, Jefferson AB, Bioorg Med Chem Lett. 2006 Aug 15;16(16):4163-8. Epub 2006 Jun 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16765046 16765046]
Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies., Lin X, Murray JM, Rico AC, Wang MX, Chu DT, Zhou Y, Del Rosario M, Kaufman S, Ma S, Fang E, Crawford K, Jefferson AB, Bioorg Med Chem Lett. 2006 Aug 15;16(16):4163-8. Epub 2006 Jun 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16765046 16765046]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Protein complex]]
[[Category: Murray, J M.]]
[[Category: Murray, J M.]]
[[Category: akt]]
[[Category: Akt]]
[[Category: camp-dependent protein kinase]]
[[Category: Camp-dependent protein kinase]]
[[Category: drug design]]
[[Category: Drug design]]
[[Category: kinase]]
[[Category: Kinase]]
[[Category: pka]]
[[Category: Pka]]
[[Category: ternary complex]]
[[Category: Ternary complex]]
 
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