6co1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6co1 is ~~ON HOLD~~ ~~until Paper Publication~~

==Structure of human TIRR in complex with 53BP1 Tudor domains==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6co1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CO1 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6co1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6co1 OCA], [http://pdbe.org/6co1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6co1 RCSB], [http://www.ebi.ac.uk/pdbsum/6co1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6co1 ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.

== Function ==

[[http://www.uniprot.org/uniprot/TIRR_HUMAN TIRR_HUMAN]] Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).<ref>PMID:18820299</ref> <ref>PMID:28241136</ref> [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Botuyan, M V]]

[[Category: Cui, G]]

[[Category: Mer, G]]

[[Category: Dna damage response]]

[[Category: Dna damage signaling]]

[[Category: Dna repair]]

[[Category: Nudt16l1]]

[[Category: Protein binding]]

[[Category: Tirr]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6co1 is ON HOLD  until Paper Publication
+==Structure of human TIRR in complex with 53BP1 Tudor domains==
+<StructureSection load='6co1' size='340' side='right' caption='[[6co1]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6co1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CO1 FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6co1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6co1 OCA], [http://pdbe.org/6co1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6co1 RCSB], [http://www.ebi.ac.uk/pdbsum/6co1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6co1 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
+== Function ==
+[[http://www.uniprot.org/uniprot/TIRR_HUMAN TIRR_HUMAN]] Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).<ref>PMID:18820299</ref> <ref>PMID:28241136</ref>  [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Botuyan, M V]]
+[[Category: Cui, G]]
+[[Category: Mer, G]]
+[[Category: Dna damage response]]
+[[Category: Dna damage signaling]]
+[[Category: Dna repair]]
+[[Category: Nudt16l1]]
+[[Category: Protein binding]]
+[[Category: Tirr]]